Transform DGE matrix¶
Each differential gene expression (DGE) matrix needs to be transformed to Ideogram JSON.
The dge_to_ideogram.py CLI module converts a DGE matrix file containing gene expression summary statistics into an Ideogram.js annotations JSON file. The resulting JSON file is used for exploratory data analysis as demonstrated at:
https://eweitz.github.io/ideogram/differential-expression
DGE matrix format¶
The DGE matrix has several groups of columns, with headers ordered like so:
metadata: “REFSEQ”,”SYMBOL”,”GENENAME”,”ENSEMBL”,”ENTREZID”,”STRING_id”,”GOSLIM_IDS”
replicates: <sample_prefix>-<group>-<replicate_number>, e.g. “Mmus-C57-6T-TMS-FLT-Rep1”
stats: “All.mean”,”All.stdev”,”F.p.value”
stats_by_group: Group.<stat>_(<group>), e.g. “Group.Mean_(Space Flight)”
stats_by_comparison: <stat>_(<group1>)v(<group2>), e.g. “Log2fc_(Ground Control)v(Space Flight)”
Example DGE matrix¶
An example DGE matrix is GLDS-21_array_differential_expression.csv from GLDS-21, produced by NASA GeneLab. Below is an excerpt.
# Download example DGE matrix
curl -L https://genelab-data.ndc.nasa.gov/genelab/static/media/dataset/GLDS-21_array_differential_expression.csv?version=1 > GLDS-21_array_differential_expression.csv
# Print first 10 lines of example DGE matrix
head GLDS-21_array_differential_expression.csv
"REFSEQ","SYMBOL","GENENAME","ENSEMBL","ENTREZID","STRING_id","GOSLIM_IDS","Mmus-C57-6J-GST-M19-CTRL-Rep1","Mmus-C57-6J-GST-M1-CTRL-Rep2","Mmus-C57-6J-GST-M21-CTRL-Rep3","Mmus-C57-6J-GST-M22-CTRL-Rep4","Mmus-C57-6J-GST-M2-CTRL-Rep5","Mmus-C57-6J-GST-M14-HLU-RL-Rep1","Mmus-C57-6J-GST-M15-HLU-RL-Rep2","Mmus-C57-6J-GST-M16-HLU-RL-Rep3","Mmus-C57-6J-GST-M18-HLU-RL-Rep4","Mmus-C57-6J-GST-M33-HLU-RL-Rep5","Mmus-C57-6J-GST-M11-HLU-Rep1","Mmus-C57-6J-GST-M25-HLU-Rep2","Mmus-C57-6J-GST-M30-HLU-Rep3","Mmus-C57-6J-GST-M8-HLU-Rep4","Mmus-C57-6J-GST-M9-HLU-Rep5","Mmus-C57-6J-GST-M1-GC-Rep1","Mmus-C57-6J-GST-M2-GC-Rep2","Mmus-C57-6J-GST-M3-GC-Rep3","Mmus-C57-6J-GST-M4-GC-Rep4","Mmus-C57-6J-GST-M10-FLT-Rep1","Mmus-C57-6J-GST-M11-FLT-Rep2","Mmus-C57-6J-GST-M8-FLT-Rep3","Mmus-C57-6J-GST-M9-FLT-Rep4","All.mean","All.stdev","F.p.value","Group.Mean_(Vivarium Control)","Group.Mean_(Hindlimb Suspension and Reloading)","Group.Mean_(Hindlimb Suspension)","Group.Mean_(Ground Control)","Group.Mean_(Space Flight)","Group.Stdev_(Vivarium Control)","Group.Stdev_(Hindlimb Suspension and Reloading)","Group.Stdev_(Hindlimb Suspension)","Group.Stdev_(Ground Control)","Group.Stdev_(Space Flight)","Log2fc_(Ground Control)v(Hindlimb Suspension and Reloading)","Log2fc_(Ground Control)v(Hindlimb Suspension)","Log2fc_(Ground Control)v(Space Flight)","Log2fc_(Ground Control)v(Vivarium Control)","Log2fc_(Hindlimb Suspension and Reloading)v(Hindlimb Suspension)","Log2fc_(Hindlimb Suspension and Reloading)v(Space Flight)","Log2fc_(Hindlimb Suspension and Reloading)v(Vivarium Control)","Log2fc_(Hindlimb Suspension)v(Space Flight)","Log2fc_(Hindlimb Suspension)v(Vivarium Control)","Log2fc_(Space Flight)v(Vivarium Control)","Log2fc_(Hindlimb Suspension and Reloading)v(Ground Control)","Log2fc_(Hindlimb Suspension)v(Ground Control)","Log2fc_(Space Flight)v(Ground Control)","Log2fc_(Vivarium Control)v(Ground Control)","Log2fc_(Hindlimb Suspension)v(Hindlimb Suspension and Reloading)","Log2fc_(Space Flight)v(Hindlimb Suspension and Reloading)","Log2fc_(Vivarium Control)v(Hindlimb Suspension and Reloading)","Log2fc_(Space Flight)v(Hindlimb Suspension)","Log2fc_(Vivarium Control)v(Hindlimb Suspension)","Log2fc_(Vivarium Control)v(Space Flight)","P.value_(Ground Control)v(Hindlimb Suspension and Reloading)","P.value_(Ground Control)v(Hindlimb Suspension)","P.value_(Ground Control)v(Space Flight)","P.value_(Ground Control)v(Vivarium Control)","P.value_(Hindlimb Suspension and Reloading)v(Hindlimb Suspension)","P.value_(Hindlimb Suspension and Reloading)v(Space Flight)","P.value_(Hindlimb Suspension and Reloading)v(Vivarium Control)","P.value_(Hindlimb Suspension)v(Space Flight)","P.value_(Hindlimb Suspension)v(Vivarium Control)","P.value_(Space Flight)v(Vivarium Control)","P.value_(Hindlimb Suspension and Reloading)v(Ground Control)","P.value_(Hindlimb Suspension)v(Ground Control)","P.value_(Space Flight)v(Ground Control)","P.value_(Vivarium Control)v(Ground Control)","P.value_(Hindlimb Suspension)v(Hindlimb Suspension and Reloading)","P.value_(Space Flight)v(Hindlimb Suspension and Reloading)","P.value_(Vivarium Control)v(Hindlimb Suspension and Reloading)","P.value_(Space Flight)v(Hindlimb Suspension)","P.value_(Vivarium Control)v(Hindlimb Suspension)","P.value_(Vivarium Control)v(Space Flight)","Adj.p.value_(Ground Control)v(Hindlimb Suspension and Reloading)","Adj.p.value_(Ground Control)v(Hindlimb Suspension)","Adj.p.value_(Ground Control)v(Space Flight)","Adj.p.value_(Ground Control)v(Vivarium Control)","Adj.p.value_(Hindlimb Suspension and Reloading)v(Hindlimb Suspension)","Adj.p.value_(Hindlimb Suspension and Reloading)v(Space Flight)","Adj.p.value_(Hindlimb Suspension and Reloading)v(Vivarium Control)","Adj.p.value_(Hindlimb Suspension)v(Space Flight)","Adj.p.value_(Hindlimb Suspension)v(Vivarium Control)","Adj.p.value_(Space Flight)v(Vivarium Control)","Adj.p.value_(Hindlimb Suspension and Reloading)v(Ground Control)","Adj.p.value_(Hindlimb Suspension)v(Ground Control)","Adj.p.value_(Space Flight)v(Ground Control)","Adj.p.value_(Vivarium Control)v(Ground Control)","Adj.p.value_(Hindlimb Suspension)v(Hindlimb Suspension and Reloading)","Adj.p.value_(Space Flight)v(Hindlimb Suspension and Reloading)","Adj.p.value_(Vivarium Control)v(Hindlimb Suspension and Reloading)","Adj.p.value_(Space Flight)v(Hindlimb Suspension)","Adj.p.value_(Vivarium Control)v(Hindlimb Suspension)","Adj.p.value_(Vivarium Control)v(Space Flight)"
"NM_013477","Atp6v0d1","ATPase, H+ transporting, lysosomal V0 subunit D1","ENSMUSG00000013160","11972",NA,"GO:0003824, GO:0005215, GO:0006810, GO:0006811, GO:0006812, GO:0008324, GO:0015078, GO:0016787, GO:0022857, GO:0008152, GO:0051179",7.7257820950506,7.84313596519635,7.92196078756618,7.97589186470181,7.61839761490813,8.03409884224697,7.99157996281313,7.8050344911136,8.0891594337366,7.97378740316215,7.15547234247511,7.91405159713476,7.72493982766783,7.55328424180865,7.54464701803143,8.35918865982752,8.24377032548604,8.34427162732955,8.34482075283258,8.36167982612162,8.25621683710273,8.41104483446799,8.32697396108158,7.97909523095056,0.0282776063242181,2.03287461813406e-06,8.32301284136892,7.57847900542356,7.97873202661449,8.33897886469348,7.81703366548461,4.16150642068446,3.38919884443641,3.56819743715293,4.16948943234674,3.49588373168559,0.744533835945366,0.344280814754432,-0.0159660233245571,0.505979175884309,-0.400253021190934,-0.760499859269923,-0.238554660061057,-0.360246838078989,0.161698361129877,0.521945199208866,-0.744533835945366,-0.344280814754432,0.0159660233245571,-0.505979175884309,0.400253021190934,0.760499859269923,0.238554660061057,0.360246838078989,-0.161698361129877,-0.521945199208866,1.39848603457645e-06,0.00596001736520029,0.894438821528775,0.000194730292332154,0.00111028552834159,1.02256465728364e-06,0.0355777788013318,0.00429005146391487,0.143025685222599,0.000138451040149514,1.39848603457645e-06,0.00596001736520029,0.894438821528775,0.000194730292332154,0.00111028552834159,1.02256465728364e-06,0.0355777788013318,0.00429005146391487,0.143025685222599,0.000138451040149514,2.59951479789537e-05,0.0225242443781023,0.999966010284893,0.00194425788356654,0.161370011235908,1.54169429439341e-05,0.242275153466606,0.014447246095515,0.999991739420172,0.00107282753805176,2.59951479789537e-05,0.0225242443781023,0.999966010284893,0.00194425788356654,0.161370011235908,1.54169429439341e-05,0.242275153466606,0.014447246095515,0.999991739420172,0.00107282753805176
"NM_001042484","Golga7","golgi autoantigen, golgin subfamily a, 7","ENSMUSG00000015341","57437",NA,"GO:0003824, GO:0005622, GO:0005737, GO:0005794, GO:0006464, GO:0006497, GO:0006605, GO:0006810, GO:0006886, GO:0008104, GO:0008152, GO:0009058, GO:0009987, GO:0015031, GO:0016043, GO:0016192, GO:0016740, GO:0016746, GO:0019538, GO:0032991, GO:0043226, GO:0043234, GO:0044238, GO:0044464, GO:0051179, GO:0071840",8.73243428421421,8.47265380141892,8.77071071861314,8.60891537447205,8.64612515594437,8.69056769224593,8.71110585060474,8.71393475048357,8.57994830337183,8.74384607040437,6.59566688844254,8.87991401739975,8.76274698871946,8.14604762785509,8.44873826358109,9.30634876836969,9.0650235670456,9.06884271394723,9.13873131245664,9.1350482687313,8.94483822547572,9.0563425770422,9.13555784621569,8.71104735074153,0.171885650625696,0.0138047337182277,9.14473659045479,8.16662275719959,8.68788053342209,9.06794672936623,8.64616786693254,4.57236829522739,3.65222472633901,3.88533829062578,4.53397336468311,3.8666838190671,0.978113833255202,0.4568560570327,0.076789861088562,0.498568723522252,-0.521257776222502,-0.90132397216664,-0.47954510973295,-0.380066195944138,0.041712666489552,0.42177886243369,-0.978113833255202,-0.4568560570327,-0.076789861088562,-0.498568723522252,0.521257776222502,0.90132397216664,0.47954510973295,0.380066195944138,-0.041712666489552,-0.42177886243369,0.00200100545517407,0.115036499678786,0.795869217192227,0.087149792786443,0.0597381365920112,0.00384094662787054,0.0813673994934013,0.185920886566873,0.875094197085245,0.143985974839089,0.00200100545517407,0.115036499678786,0.795869217192227,0.087149792786443,0.0597381365920112,0.00384094662787054,0.0813673994934013,0.185920886566873,0.875094197085245,0.143985974839089,0.00482584318462189,0.203831844165131,0.999966010284893,0.166776989941987,0.224211271219303,0.00738576847431212,0.256816952952497,0.272531452798223,0.999991739420172,0.223143312948443,0.00482584318462189,0.203831844165131,0.999966010284893,0.166776989941987,0.224211271219303,0.00738576847431212,0.256816952952497,0.272531452798223,0.999991739420172,0.223143312948443
"NM_133900","Psph","phosphoserine phosphatase","ENSMUSG00000029446","100678",NA,"GO:0003824, GO:0005488, GO:0005622, GO:0005737, GO:0006520, GO:0006796, GO:0006807, GO:0008152, GO:0008652, GO:0009058, GO:0009987, GO:0016787, GO:0016788, GO:0016791, GO:0044238, GO:0044464",4.86066785235675,4.85395026121031,4.93327403838069,5.05004369537868,4.7478500715842,4.74734097563494,4.98755847675237,4.96372179595896,5.02245488465075,4.97964714916791,4.35250955980416,4.94529632704556,5.0583490019893,4.89441712517217,5.12267612594413,6.14762517119975,5.86480970295413,5.76077647345354,5.7865402625027,5.91181373094812,5.82793376063711,5.8906715699905,5.79254533009815,5.23923797142673,0.0333456325100968,2.44663857184323e-09,5.88993790252753,4.87464962799106,4.94014465643299,5.85574109791847,4.88915718378212,2.94496895126376,2.18000958693642,2.2092998540933,2.92787054895923,2.18649756312365,1.01528827453647,0.949793246094543,0.0341968046090591,1.0007807187454,-0.0654950284419229,-0.981091469927406,-0.0145075557910612,-0.915596441485484,0.0509874726508617,0.966583914136345,-1.01528827453647,-0.949793246094543,-0.0341968046090591,-1.0007807187454,0.0654950284419229,0.981091469927406,0.0145075557910612,0.915596441485484,-0.0509874726508617,-0.966583914136345,3.97212622804918e-08,1.17764923990239e-07,0.793663492112051,5.03669409514894e-08,0.57653717865235,6.97262675567756e-08,0.901206460598853,2.10892623811735e-07,0.663283970863826,8.88039225813255e-08,3.97212622804918e-08,1.17764923990239e-07,0.793663492112051,5.03669409514894e-08,0.57653717865235,6.97262675567756e-08,0.901206460598853,2.10892623811735e-07,0.663283970863826,8.88039225813255e-08,3.26955400012536e-06,1.93683470368805e-05,0.999966010284893,1.45682740139007e-05,0.675695647154048,2.64214966379829e-06,0.932002660868356,1.27635014505965e-05,0.999991739420172,8.17323336511723e-06,3.26955400012536e-06,1.93683470368805e-05,0.999966010284893,1.45682740139007e-05,0.675695647154048,2.64214966379829e-06,0.932002660868356,1.27635014505965e-05,0.999991739420172,8.17323336511723e-06
"NM_021789","Trappc4","trafficking protein particle complex 4","ENSMUSG00000032112","60409",NA,"GO:0000166, GO:0003824, GO:0003924, GO:0005083, GO:0005085, GO:0005488, GO:0005622, GO:0006139, GO:0006796, GO:0006807, GO:0006810, GO:0008152, GO:0009056, GO:0009987, GO:0016192, GO:0016462, GO:0016787, GO:0030234, GO:0032991, GO:0043234, GO:0044238, GO:0044464, GO:0050789, GO:0050790, GO:0051179, GO:0065007, GO:0065009",6.86453094082816,6.95638709228716,6.93785154771474,6.9486345783565,6.59222784139469,6.75181927301955,6.89771530818833,6.54459667307327,6.74110826988262,6.87764590359797,6.35985747965413,6.62911491193238,6.7813538001846,6.41208543663296,6.93134932536261,7.59330837488809,7.65662035729898,7.20010997801657,7.37658626457963,7.20608578453671,7.05929575253853,7.75862969747448,7.42656569165268,6.97841218622154,0.0446230750445414,1.09489678297805e-05,7.45665624369582,6.62275219075334,6.76257708555235,7.3626442315506,6.85992640011625,3.72832812184791,2.96178481933202,3.02431641327549,3.6813221157753,3.06785235026107,0.833904052942482,0.694079158143471,0.0940120121452193,0.596729843579569,-0.139824894799011,-0.739892040797263,-0.237174209362913,-0.600067145998252,-0.0973493145639024,0.502717831434349,-0.833904052942482,-0.694079158143471,-0.0940120121452193,-0.596729843579569,0.139824894799011,0.739892040797263,0.237174209362913,0.600067145998252,0.0973493145639024,-0.502717831434349,7.06987423791989e-06,7.22064960303289e-05,0.53574491300652,0.000377643571619844,0.306947532554226,3.34122366049216e-05,0.0900576656311043,0.000356767187298876,0.474096451733305,0.00186000474881377,7.06987423791989e-06,7.22064960303289e-05,0.53574491300652,0.000377643571619844,0.306947532554226,3.34122366049216e-05,0.0900576656311043,0.000356767187298876,0.474096451733305,0.00186000474881377,7.47369983594678e-05,0.00095453100859969,0.999966010284893,0.00309114057196795,0.437566420039904,0.000181873086719885,0.259558775180826,0.00215554435623863,0.999991739420172,0.00758784845670623,7.47369983594678e-05,0.00095453100859969,0.999966010284893,0.00309114057196795,0.437566420039904,0.000181873086719885,0.259558775180826,0.00215554435623863,0.999991739420172,0.00758784845670623
"NM_010073","Dpm2","dolichol-phosphate (beta-D) mannosyltransferase 2","ENSMUSG00000026810","13481",NA,"GO:0003824, GO:0005622, GO:0005737, GO:0005783, GO:0005975, GO:0006464, GO:0006486, GO:0006497, GO:0006629, GO:0006644, GO:0006796, GO:0008152, GO:0009058, GO:0009987, GO:0016020, GO:0016740, GO:0016757, GO:0019538, GO:0030234, GO:0032991, GO:0042175, GO:0043226, GO:0043234, GO:0044238, GO:0044464, GO:0050789, GO:0050790, GO:0065007, GO:0065009",7.43251664828479,7.40034107493916,7.68505466921833,7.43623308853643,7.42341754145451,7.58558160457673,7.54197807107685,7.34245916718447,7.38456050585125,7.43572541017978,7.32550553659207,7.25206502700328,7.4396924490844,7.42549306000687,7.3578712328388,7.44140937172973,7.47235113367852,7.48503517065137,7.61458652583076,7.5035124858343,7.40665782584212,7.41309865421363,7.5093035753219,7.44845434043174,0.0134569002185024,0.413441717187866,7.5033455504726,7.36012546110508,7.45806095177382,7.45814313530299,7.47551260448665,3.7516727752363,3.29154817079159,3.33534625370061,3.72907156765149,3.34315087005773,0.143220089367512,0.0452845986987809,0.0452024151696087,0.0278329459859492,-0.0979354906687311,-0.0980176741979033,-0.115387143381563,-8.21835291722195e-05,-0.0174516527128317,-0.0173694691836594,-0.143220089367512,-0.0452845986987809,-0.0452024151696087,-0.0278329459859492,0.0979354906687311,0.0980176741979033,0.115387143381563,8.21835291722195e-05,0.0174516527128317,0.0173694691836594,0.0795862601252623,0.566682535664377,0.587285574201185,0.72408870344509,0.195923579135489,0.221361484841036,0.130423254288774,0.999167117868982,0.814242894433413,0.825487438078494,0.0795862601252623,0.566682535664377,0.587285574201185,0.72408870344509,0.195923579135489,0.221361484841036,0.130423254288774,0.999167117868982,0.814242894433413,0.825487438078494,0.100975314634834,0.662747136224388,0.999966010284893,0.788018812254457,0.334708241546515,0.250801717808537,0.286082379884573,0.999401902967564,0.999991739420172,0.867396904818759,0.100975314634834,0.662747136224388,0.999966010284893,0.788018812254457,0.334708241546515,0.250801717808537,0.286082379884573,0.999401902967564,0.999991739420172,0.867396904818759
"NM_011186","Psmb5","proteasome (prosome, macropain) subunit, beta type 5","ENSMUSG00000022193","19173",NA,"NA",10.4173824798625,10.4990702482183,10.6447732811381,10.5501469157437,10.5209031983952,10.3922555227939,10.5743274224454,10.2677063976684,10.4528265665837,10.4135204585091,8.12120679239209,10.519152233801,10.3692944750937,10.2372609439318,10.3485335430108,10.9254503733778,10.7862150372581,10.9361517053036,10.8895814813605,10.7514505837285,10.6842716500414,10.7715724998152,10.8084923910256,10.473110704413,0.201455965728848,0.03421279980501,10.884349649325,9.91908959764588,10.4201272736001,10.7539467811527,10.5264552246716,5.4421748246625,4.43595172304944,4.66002258359387,5.37697339057634,4.70757388889469,0.965260051679119,0.4642223757249,0.130402868172322,0.357894424653436,-0.501037675954219,-0.834857183506797,-0.607365627025683,-0.333819507552578,-0.106327951071464,0.227491556481114,-0.965260051679119,-0.4642223757249,-0.130402868172322,-0.357894424653436,0.501037675954219,0.834857183506797,0.607365627025683,0.333819507552578,0.106327951071464,-0.227491556481114,0.00416810674033423,0.137752767902032,0.685240373129938,0.24757282067751,0.0918020935349357,0.0112663932782583,0.044038508671896,0.279841086835283,0.711663297084332,0.458134464886741,0.00416810674033423,0.137752767902032,0.685240373129938,0.24757282067751,0.0918020935349357,0.0112663932782583,0.044038508671896,0.279841086835283,0.711663297084332,0.458134464886741,0.0086239019886695,0.231400006065372,0.999966010284893,0.355501880362283,0.242941577592378,0.018006488380896,0.242275153466606,0.374431127293228,0.999991739420172,0.548712916582601,0.0086239019886695,0.231400006065372,0.999966010284893,0.355501880362283,0.242941577592378,0.018006488380896,0.242275153466606,0.374431127293228,0.999991739420172,0.548712916582601
"NM_026819","Dhrs1","dehydrogenase/reductase (SDR family) member 1","ENSMUSG00000002332","52585",NA,"NA",7.30878427447465,7.23694159902284,7.23694159902284,7.28344547527175,7.32374234290042,7.14275255493379,7.29836625622201,7.1341174174193,7.21385434233633,7.23357835674116,7.29669408158391,7.2240345696726,7.25660031214864,7.23682095017222,7.28008608624929,7.04936184168956,7.08817567357559,7.24600272972142,7.27843743700347,7.06348665776695,7.22123755103474,7.39107448460253,7.06626770228387,7.22220888242826,0.0130512091683326,0.53492915172593,7.16549442049751,7.25884719996533,7.20453378553052,7.18551659892202,7.2779710581385,3.58274721024875,3.2462551554813,3.22196545812803,3.59275829946101,3.25480760485475,-0.0933527794678204,-0.0390393650330072,-0.0200221784245134,-0.112476637640987,0.0543134144348132,0.073330601043307,-0.0191238581731668,0.0190171866084938,-0.0734372726079799,-0.0924544592164738,0.0933527794678204,0.0390393650330072,0.0200221784245134,0.112476637640987,-0.0543134144348132,-0.073330601043307,0.0191238581731668,-0.0190171866084938,0.0734372726079799,0.0924544592164738,0.236408941714921,0.615665466089051,0.806603619829904,0.156710218133885,0.460397329345376,0.349298763292063,0.793784416787628,0.806379598057849,0.320776572413807,0.240802556281558,0.236408941714921,0.615665466089051,0.806603619829904,0.156710218133885,0.460397329345376,0.349298763292063,0.793784416787628,0.806379598057849,0.320776572413807,0.240802556281558,0.268780465251027,0.705303716832715,0.999966010284893,0.255449257795469,0.575440334319316,0.381928693144931,0.85339510038542,0.852401719270693,0.999991739420172,0.331541632745606,0.268780465251027,0.705303716832715,0.999966010284893,0.255449257795469,0.575440334319316,0.381928693144931,0.85339510038542,0.852401719270693,0.999991739420172,0.331541632745606
"NM_008910","Ppm1a","protein phosphatase 1A, magnesium dependent, alpha isoform","ENSMUSG00000021096","19042",NA,"GO:0000165, GO:0003824, GO:0004721, GO:0004857, GO:0005488, GO:0005515, GO:0006464, GO:0006468, GO:0007154, GO:0007165, GO:0008152, GO:0009987, GO:0016787, GO:0016788, GO:0016791, GO:0019207, GO:0019210, GO:0019538, GO:0030234, GO:0035556, GO:0044238, GO:0050790, GO:0065007, GO:0065009",10.2370668098058,10.146998463959,10.1686637334362,10.2064002643757,10.2287575926057,10.1331254886193,10.1577175591567,10.0327745993425,10.1903309700602,10.0707354085838,6.89873257226107,10.1326324940361,10.2025848380022,9.82831040481749,10.322918704684,10.539373290756,10.3399052916396,10.52107130054,10.714328811621,10.5204195281321,10.5363738400327,10.3228666740627,10.3988212136359,10.123952602355,0.406108489256907,0.136793545080982,10.5286696736392,9.47703580276017,10.1169368051525,10.4446203139658,10.1975773728365,5.26433483681958,4.23825925603421,4.52443168407811,5.22231015698292,4.56049524229522,1.05163387087898,0.411732868486649,0.0840493596733012,0.331092300802672,-0.639901002392332,-0.967584511205679,-0.720541570076309,-0.327683508813347,-0.080640567683977,0.24704294112937,-1.05163387087898,-0.411732868486649,-0.0840493596733012,-0.331092300802672,0.639901002392332,0.967584511205679,0.720541570076309,0.327683508813347,0.080640567683977,-0.24704294112937,0.022454534419192,0.346217138358068,0.853789690555001,0.447092774810973,0.126999608250982,0.034098121512033,0.0879608778055581,0.451721412899901,0.84330412901312,0.569359037898152,0.022454534419192,0.346217138358068,0.853789690555001,0.447092774810973,0.126999608250982,0.034098121512033,0.0879608778055581,0.451721412899901,0.84330412901312,0.569359037898152,0.0336712546422125,0.459867406281112,0.999966010284893,0.552377586526329,0.271564801970034,0.0469976267359592,0.257897212486433,0.544350518328936,0.999991739420172,0.651916172657653,0.0336712546422125,0.459867406281112,0.999966010284893,0.552377586526329,0.271564801970034,0.0469976267359592,0.257897212486433,0.544350518328936,0.999991739420172,0.651916172657653
"NM_025498","Psenen","presenilin enhancer gamma secretase subunit","ENSMUSG00000036835","66340",NA,"GO:0005886, GO:0016020, GO:0032991, GO:0043234, GO:0044464",9.75392835561914,9.74987430120933,9.93583953479859,9.93382155866816,9.76327439364241,9.74000573921616,9.91120717844081,9.63793061755572,9.68663642313116,9.81913412138686,7.29199382929261,9.96188296867934,9.62645287651746,9.71584419494504,9.78372625711475,10.2277886712033,10.1655910243692,10.2070187039487,10.2241072860301,10.2229225135366,10.2752745910896,10.25162938515,10.1381634065352,9.8271325187861,0.243458411980911,0.050888166544347,10.2061264213878,9.27598002530984,9.75898281594614,10.2219974740779,9.82734762878752,5.10306321069391,4.1483443789046,4.36434979354158,5.11099873703893,4.39492346729805,0.930146396077985,0.447143605441685,-0.0158710526900254,0.378778792600302,-0.4830027906363,-0.946017448768011,-0.551367603477683,-0.46301465813171,-0.0683648128413825,0.394649845290328,-0.930146396077985,-0.447143605441685,0.0158710526900254,-0.378778792600302,0.4830027906363,0.946017448768011,0.551367603477683,0.46301465813171,0.0683648128413825,-0.394649845290328,0.0103563336793443,0.190808706430109,0.964138436816396,0.265085844794998,0.136312714305422,0.00929132341712647,0.0914886662440544,0.17615408535817,0.828664828172563,0.246165852258643,0.0103563336793443,0.190808706430109,0.964138436816396,0.265085844794998,0.136312714305422,0.00929132341712647,0.0914886662440544,0.17615408535817,0.828664828172563,0.246165852258643,0.0177347699820349,0.296343962138762,0.999966010284893,0.373265656415496,0.279697105281305,0.0153136551415469,0.260859803196553,0.261385971418061,0.999991739420172,0.337414037862577,0.0177347699820349,0.296343962138762,0.999966010284893,0.373265656415496,0.279697105281305,0.0153136551415469,0.260859803196553,0.261385971418061,0.999991739420172,0.337414037862577